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Clinical News
For pharmacists, from Drug Topics: News and features for pharmacists about clinical trials, newly approved drugs, and new practices in clinical pharmacy

FDA grants priority review to GI agent for controlling diarrhea in HIV/AIDS patients

February 7, 2012

FDA has granted priority review to crofelemer 125-mg tablets (Salix Pharmaceuticals) for the control and symptomatic relief of diarrhea in patients with HIV/AIDS on anti-retroviral therapy (ART).

FDA approves extended-release tablets for type 2 diabetes

February 3, 2012

FDA approved sitagliptin and metformin hydrochloride (HCl) extended-release (Janumet XR, Merck) tablets, a new treatment for type 2 diabetes that combines sitagliptin, which is the active component of Januvia (sitagliptin), with extended-release metformin.

FDA approves ivacaftor to treat rare form of cystic fibrosis

February 1, 2012

FDA approved ivacaftor (Kalydeco, Vertex Pharmaceuticals) for the treatment of a rare form of cystic fibrosis in patients aged 6 years and older who have the specific G551D mutation in the Cystic Fibrosis Transmembrane Regulator gene.

Review raises questions about why government stockpiling zanamivir, oseltamivir

January 31, 2012

Zanamivir and oseltamivir (Tamiflu, Roche) can help prevent and treat the symptoms of influenza, but there is not enough information to evaluate the drugs’ safety and efficacy for preventing the spread of flu or pneumonia, according to a new review published online January 18.

New guidelines recommend blood-glucose testing for all hospitalized patients

January 26, 2012

The Endocrine Society recently released new clinical-practice guidelines recommending that all patients have their blood-glucose levels tested upon admission to the hospital, even if they haven’t had a prior diagnosis of diabetes.

Use of aspirin questioned as primary prevention for CVD

January 26, 2012

Aspirin prophylaxis in people without prior cardiovascular disease does not appear to reduce cardiovascular death or cancer mortality, however it was associated with reductions in nonfatal myocardial infarction, according to the results of a meta-analysis published online January 9 in the Archives of Internal Medicine.

Study: Blood clots likely for as many as 1 in 100 following joint replacements

January 26, 2012

Approximately 1 in 100 patients undergoing total or partial knee replacement surgery and 1 in 200 patients undergoing total or partial hip replacement surgery will experience a venous thromboembolism event, including deep vein thrombosis and pulmonary embolism, before being discharged from the hospital, according to a study reported January 18 in the Journal of the American Medical Association.

Anti-infective drug shortages affect clinical care, outcomes

January 26, 2012

Welcome to the latest public health emergency: Shortages of anti-infective agents. These shortages can adversely affect clinical care and patient outcomes, according to a new study.

Ranbaxy accepts consent decree, permanent injunction

January 26, 2012

Indian drug giant Ranbaxy has accepted a consent decree filed by the U.S. Department of Justice on behalf of FDA. The decree, which must still be accepted by the U.S. District Court for the District of Maryland, requires Ranbaxy to fix long-standing manufacturing problems at plants in India as well as a plant in the United States.

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Drug Topics is a monthly news magazine, guided by a board of pharmacy leaders, reporting on all phases of community, retail, and health-system issues and trends. We cover managed care and professional, national, and state activities as well as new therapies involving prescription and OTC drugs.
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