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    Small Doses: March 2018 Edition

    Easy-to-swallow news and studies for the busy pharmacist.



    Certain Antithyroid Drugs May Cause Birth Defects

    Antithyroid drugs (ATDs) taken during the first trimester of pregnancy are associated with an increased risk of birth defects, according to a new study.

    Prenatal exposure to methimazole (MMI, Tapazole) and propylthiouracil (PTU) resulted in relative increases in the risk for congenital malformations of 31% and 16%, respectively, according to a South Korean study published in Annals of Internal Medicine.

    The increased risk for malformations associated with MMI remained among those who switched to PTU several months before their pregnancy or during the first trimester.

    The study included a cohort of more than 2.8 million pregnancies that resulted in live births between 2008 and 2010.

    Of the total pregnancies, 12,891 pregnancies were exposed to ATDs during the first trimester.

    “Exposure to ATDs during the first trimester was associated with increased risk for congenital malformations, particularly for pregnancies in which women received prescriptions for MMI or both ATDs,” the researchers wrote.

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