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    Small Doses: Pharmacy News Featuring Opioids, Ketamine, and More

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    Depression

    British Study Recommends Controlled Use of Ketamine for Severe Depression

    Ketamine, legally used in anesthesiology and illegally used as a party drug, is safe and effective for use as a treatment for severe depression that has not been helped by other treatments. This is the finding of a review in The Lancet Psychiatry conducted by a team from Oxford. The authors note that ketamine should be used only under controlled conditions and warned against “ketamine clinics” that have popped up in the United States, according to a Reuters report. Their review concluded with recommendations for “oversight bodies that would support safe, effective, and ethical use of ketamine in depression.” Doses used in trials of ketamine for severe depression were around 80 mg and given once a week in a monitored setting. The American Psychiatric Association has issued a consensus statement on the appropriate use of ketamine in patients who do not respond to regular antidepressants.

    Singh I, Morgan C, Curran V, et al.: Ketamine treatment for depression: Opportunities for clinical innovation and ethical foresight. Lancet Psych. doi: http://dx.doi.org/10.1016/

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    Valerie DeBenedette
    Valerie DeBenedette is Managing Editor of Drug Topics.

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