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    Walking over a pill

    What Are the Best Drugs for Diabetic Neuropathy? A Review Narrows Down the Field.

    Certain drugs appear to do better than others at treating pain and numbness due to diabetic peripheral neuropathy, according to a review of more than 100 published and unpublished studies. It found moderate evidence that duloxetine and venlafaxine are effective and weak evidence that pregabalin, oxcarbazepine, tricyclic antidepressants, and atypical opioids such as tramadol are more effective than placebo at reducing pain. Gabapentin was found to be no more effective than placebo. However, the study authors, led by Julie Waldfogel, PharmD, noted that few of the studies evaluated included information on whether any of these drugs had appositive effect on quality of life.

    Waldfogel JM, Nesbit SA, Dy SM, et al.: Pharmacotherapy for diabetic peripheral neuropathy pain and quality of life: A systematic review. Neurol. Published online before print March 24, 2017. 

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    Valerie DeBenedette
    Valerie DeBenedette is Managing Editor of Drug Topics.

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