• linkedin
  • Increase Font
  • Sharebar

    Small Doses: News for Pharmacists

    The news you need in a way that works for you.


    Picture of Brain

    Drugs for Enlarged Prostate May Raise Risk of Depression and Self-Harm, But Not Suicide

    There have been concerns that 5-alpha reductase inhibitors, used to treat benign prostate enlargement, increased a man’s risk of depression, self-harm, or suicide. Now, a large retrospective study has found that these drugs (including Avodart, Jalyn, Proscar, and Propecia) appear to increase the risk of depression and self-harm, but not the risk of suicide. The Canadian study linked data for 93,197 men 66 or older who had started on a 5-alpha reductase inhibitor between 2003 and 2013 and matched them with an equal number of men who did not take the drugs. Risk of self-harm was significantly increased during the first 18 months after the drug was started, but not thereafter. Depression risk was elevated during the first 18 months, and continued to be elevated, but to a lesser degree, for the remainder of follow-up. The study was published in JAMA Internal Medicine.

    Welk B, McARthur E, Ordon M et al: Association of suicidality and depression with 5α-reductase inhibitors. JAMA Intern Med. Published online March 20, 2017. doi:10.1001/jamainternmed.2017.0089

    Previous ButtonNext Button


    Valerie DeBenedette
    Valerie DeBenedette is Managing Editor of Drug Topics.


    You must be signed in to leave a comment. Registering is fast and free!

    All comments must follow the ModernMedicine Network community rules and terms of use, and will be moderated. ModernMedicine reserves the right to use the comments we receive, in whole or in part,in any medium. See also the Terms of Use, Privacy Policy and Community FAQ.

    • No comments available
    Your 10 Worst Pharmacy Mistakes
    Your 10 Worst Pharmacy Mistakes

    In pharmacy, mistakes are serious, but they still happen. You wrote in with the mistakes that have stuck with you—and ...

    10 Old Remedies You Won't Find ...
    2018 Novel Drug Approvals: The First ...
    Five Tips for Surviving a 12-Hour ...