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    Apixaban cuts stroke risk regardless of BP control


    Anna GarrettAnna GarrettPoor blood pressure control is associated with a substantially higher risk of stroke or systemic embolism in patients with atrial fibrillation. A subanalysis of the Phase 3 ARISTOTLE trial indicates that apixaban reduces the risk of stroke regardless of whether a patient’s blood pressure is controlled.

    In ARISTOTLE, a total of 15,916 (87.5%) patients had a history of hypertension requiring treatment. During the trial, 50% of patients had poorly controlled hypertension (defined as systolic blood pressure >140 mm Hg and/or diastolic blood pressure >90 mm Hg) at some point. Poorly controlled hypertension during the course of the trial was associated with a significant 53% increase in the risk of stroke or systemic embolism. Apixaban was consistent in reducing the risk of stroke or systemic embolism vs, warfarin in patients with and without poor blood pressure control during the trial.

    In this subanalysis, the effect of apixaban in reducing the risk of stroke and systemic embolism versus warfarin was consistent with the main results of the ARISTOTLE trial. These results were also consistent with the results of subanalyses of other comorbidities from the ARISTOTLE trial, which included congestive heart failure, advanced age, renal impairment, and previous stroke.

    Source: “In a subanalysis, the benefits of Eliquis (apixaban) vs. warfarin in reducing the risk of stroke in patients with nonvalvular atrial fibrillation were consistent, regardless of blood pressure control.” Press release. Princeton NJ and New York. March 27, 2014. http://bit.ly/eliquisPR. Accessed April 6, 2014.

    Anna D. Garrett, PharmD, BCPS
    Anna D. Garrett is a clinical pharmacist and president of Dr. Anna Garrett (www.drannagarrett.com). Her mission is to help women in ...


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