CLINICAL

FDA approves trifluridine/tipiracil for colorectal cancerLonsurf is a new, orally administered cytotoxic drug for the treatment of patients with metastatic colorectal cancer.
Warfarin for CKD, aspirin for TIA, and what to do about ICHAnticoagulation briefs.
Efficacy and safety of LABA/LAMA combinations in COPD: A network meta-analysisUpdate: LABA/LAMA combo therapies
The GOLD guidelines and COPD treatmentThe results of a study indicated that only 36% of COPD patients were prescribed treatment according to the GOLD guidelines. The patients that were on GOLD-recommended pharmacological therapy had a moderate improvement in symptoms and health resource utilization.
FDA approves rolapitant to prevent chemotherapy-induced nausea and vomitingRolapitant is a novel NK1 receptor antagonist that maintains >90% receptor binding up to five days after a single 180-mg dose.
USPSTF updates recommendations for aspirin useThe guidelines, which update the group's 2007 and 2009 recommendations, are published in the "Annals of Internal Medicine."
FDA warns about oral antifungal use during pregnancyA Danish study has found a possibility of increased risk of miscarriage in pregnant women who use oral fluconazole to treat yeast infections.
FDA issues a new warning about popular diabetes drugFDA approves a new indication, then issues strengthened warning about possible effects.
FDA panel favors combo IR opioidWhile the panel recommended approval of the new product, it did not find sufficient evidence for abuse-deterrent labeling.
COPD and pharmacotherapy for smoking cessation at the VA: StudyUse of tobacco-cessation therapy was low. The study found several negative factors — and two positive predictors.

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